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PMCID: PMC5568897

Tumor cells, tumor-associated macrophages, and certain dendritic cells can decrease local tryptophan levels by provoking metabolic enzymes, including indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO2) (130)

Lee SY, Usui S, Zafar AB, Oveson BC, Jo YJ, Lu LL, Masoudi S, Campochiaro PA